ATUX-1215
ATUX-1215 is an activator of protein phosphatase 2A (PP2A) . ATUX-1215 reduced the phosphorylation of ERK, p38, JNK, and Akt and the secretion of IL-12p70, GM-CSF, and IL1α in BLM-treated animals. ATUX-1215 can slow the progression of lung fibrosis[1].
Product Specifications
CAS Number
2910929-53-0
UNSPSC
12352005
Target
Apoptosis; Phosphatase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/atux-1215.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(NC1CC(OCC1)C2C3=CC=C(F)C=C3CCC4=CC(F)=CC=C42)(C5=CC=C(C=C5)OC(F)(F)F)=O
Molecular Formula
C27H24F5NO4S
Molecular Weight
553.54
References & Citations
[1]Meshach Pillai, et al. Small-Molecule Activation of Protein Phosphatase 2A Counters Bleomycin-Induced Fibrosis in Mice. 2023.|[2]Nazam N, et al., PP2A activation overcomes leptomeningeal dissemination in group 3 medulloblastoma. J Biol Chem. 2024 Nov;300 (11) :107892.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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