BMS-1166-N-piperidine-COOH
Product Specifications
UNSPSC Description
BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1[1]. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[2].
Target Antigen
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bms-1166-n-piperidine-cooh.html
Purity
97.18
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1N(CCCC1)CC2=CC(Cl)=C(C=C2OCC3=CC=CC(C#N)=C3)OCC4=CC=CC(C5=CC=C6OCCOC6=C5)=C4C)O
Molecular Weight
639.14
References & Citations
[1]Binbin Cheng, et al. Discovery of Novel Resorcinol Diphenyl Ether-Based PROTAC-like Molecules as Dual Inhibitors and Degraders of PD-L1. Eur J Med Chem. 2020 Aug 1;199:112377.|[2]Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131187/BMS-1166-N-piperidine-COOH-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131187/BMS-1166-N-piperidine-COOH-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2447066-00-2
Available Sizes
Curated Selection
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