GLP-1 (9-36) amide

GLP-1 (9-36) amide is a major metabolite of glucagon-like peptide-1- (7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4) . GLP-1 (9-36) amide acts as an antagonist to the human pancreatic GLP-1 receptor[1][2].

Product Specifications

CAS Number

[161748-29-4]

UNSPSC

12352209

Target

GCGR

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glp-1-9-36-amide.html

Purity

99.69

Solubility

DMSO : 18.18 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl) |H2O : ≥ 25 mg/mL

Smiles

C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCCNC(=N)N)C(N)=O)=O)=O)CCCCN)=O)[C@@H](C)C)=O)CC(C)C)=O)NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC(CNC([C@H](CCC(O)=O)N)=O)=O)[C@@H](C)O)=O)=O)[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)[C@H](C)C)=O)CO)=O)CO)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCN)=O)CCC(O)=O)=O)=O)[C@H](CC)C)=O)C)=O)C=4C=5C(NC4)=CC=CC5

Molecular Formula

C140H214N36O43

Molecular Weight

3089.41

References & Citations

[1]Knudsen LB, et al. Glucagon-like peptide-1- (9-36) amide is a major metabolite of glucagon-like peptide-1- (7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur J Pharmacol. 1996;318 (2-3) :429-435.|[2]Elahi D, et al. GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide. Obesity (Silver Spring) . 2008;16 (7) :1501-1509.