Desmethylglycitein

Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity[1]. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC) α, against solar UV (sUV) -induced matrix matrix metalloproteinase 1 (MMP1) [2]. Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes[3].

Product Specifications

CAS Number

[17817-31-1]

Product Name Alternative

4',6,7-Trihydroxyisoflavone

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

CDK; PI3K; PKC

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/desmethylglycitein.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C(C2=CC=C(O)C=C2)=COC3=CC(O)=C(O)C=C13

Molecular Formula

C15H10O5

Molecular Weight

270.24

Precautions

H302, H312, H332

References & Citations

[1]Lee DE, et al. 6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2. Carcinogenesis. 2011 Apr;32 (4) :629-35.|[2]Lim TG, et al. The daidzein metabolite, 6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1. Int J Mol Sci. 2014 Nov 19;15 (11) :21419-32|[3]Seo SG, et al. A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K.