15 (R) -15-Methyl prostaglandin D2
15 (R) -15-Methyl prostaglandin D2 (15 (R) -15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2. 15 (R) -15-Methyl prostaglandin D2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15 (R) -15-methyl PGD2 is >10 μM.
Product Specifications
CAS Number
[210978-26-0]
Product Name Alternative
15 (R) -15-Methyl PGD2
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/15-r-15-methyl-prostaglandin-d2.html
Purity
98.0
Smiles
CCCCC[C@@](C)(O)/C=C/[C@@H]1[C@H]([C@@H](O)CC1=O)C/C=C\CCCC(O)=O
Molecular Formula
C21H34O5
Molecular Weight
366.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Hayaishi, et al. Sleep-wake regulation by prostaglandins D2 and E2. J. Biol. Chem. 263 (29), 14593-14596 (1988) .
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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