EB-47 (dihydrochloride)

EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite[1].

Product Specifications

CAS Number

[1190332-25-2]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/eb-47-dihydrochloride.html

Purity

99.58

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

O=C1NCC2=C(C=CC=C21)NC(CN3CCN(CC3)C([C@H]4O[C@H]([C@@H]([C@@H]4O)O)N5C6=C(N=C5)C(N)=NC=N6)=O)=O.[H]Cl.[H]Cl

Molecular Formula

C24H29Cl2N9O6

Molecular Weight

610.45

References & Citations

[1]Haikarainen T, et al. Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors.ACS Med Chem Lett. 2013 Nov 20;5 (1) :18-22.|[2]García-Saura AG, et al. Comparative inhibitory profile and distribution of bacterial PARPs, using Clostridioides difficile CD160 PARP as a model. Sci Rep. 2018 May 23;8 (1) :8056.|[3]Jagtap PG, et al. The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly (ADP-ribose) polymerase-1 (PARP-1) .Bioorg Med Chem Lett. 2004 Jan 5;14 (1) :81-5.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

BioRxiv. 2025 May 15:2025.05.14.654090.|J Transl Med. 2025 Apr 30;23 (1) :492.|Nucleic Acids Res. 2023 Aug 11;51 (14) :7342-7356.|University of New Mexico. 2024 Jul 01.|Research Square Preprint. 2022 Feb.