LY-426965 (hydrochloride)
LY-426965 hydrochloride is a potent arylpiperazine compound known for its role as a full antagonist of the serotonin 1A receptor, lacking partial agonist activity. It is identified as a selective 5-HT1A antagonist, showing promise in preclinical studies for treating conditions associated with serotonin dysregulation, such as smoking cessation and depression-related disorders[1].
Product Specifications
CAS Number
326821-27-6
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ly-426965-hydrochloride.html
Smiles
O=C([C@@](C)(CCN1CCN(CC1)C2=CC=CC=C2OC)C3=CC=CC=C3)C4CCCCC4.Cl
Molecular Formula
C28H39ClN2O2
Molecular Weight
471.07
References & Citations
[1]Asymmetric Construction of Quaternary Centers by Enantioselective Allylation: Application to the Synthesis of the Serotonin Antagonist LY426965
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor
Frequently Asked Questions
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