Guaiazulene

Guaiazulene is a bicyclic sesquiterpene that can cross the blood-brain barrier. Guaiazulene exhibits various biological activities such as anti-inflammatory, antioxidant, hepatoprotective, antibacterial, and anti-tumor properties. Guaiazulene is also commonly used as a colorant in cosmetics. Guaiazulene shows in vitro cytotoxicity to rat neuronal cells and N2a neuroblastoma cells at high concentrations[1][2][3][4].

Product Specifications

CAS Number

[489-84-9]

UNSPSC

12352005

Hazard Statement

H302

Target

Akt; Apoptosis; Bacterial; Caspase; Fungal; mTOR; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/guaiazulene.html

Concentration

10mM

Purity

99.26

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C1=CC2=C(C)C=CC2=C(C)C=C1)C

Molecular Formula

C15H18

Molecular Weight

198.30

Precautions

H302

References & Citations

[1]Kourounakis AP, et al. Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats. J Pharm Pharmacol. 1997 Sep;49 (9) :938-42.|[2]Togar B, et al. Guaiazulene biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells. J Intercult Ethnopharmacol. 2015 Jan-Mar;4 (1) :29-33.|[3]Akram W, et al. Guaiazulene and related compounds: A review of current perspective on biomedical applications. Life Sci. 2023 Mar 1;316:121389.|[4]Ye Q, et al. Guaiazulene Triggers ROS-Induced Apoptosis and Protective Autophagy in Non-small Cell Lung Cancer. Front Pharmacol. 2021 Apr 15;12:621181.