A 71915
A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18) . A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915 (pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells[1].
Product Specifications
CAS Number
132956-87-7
UNSPSC
12352209
Target
Natriuretic Peptide Receptor (NPR)
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/a-71915.html
Purity
99.28
Smiles
O=C1N2[C@](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@@]1([H])[C@@H](C)CC)=O)CCCNC(N)=N)=O)CC(O)=O)=O)([H])[C@@H](C)CC)=O)CCCNC(N)=N)=O)=O)=O)CC3CCCCC3)=O)NC([C@@H](N)CCCNC(N)=N)=O)C(N)=O)=O)CCCNC(N)=N)=O)([H])CC4=CC=CC=C4C2
Molecular Formula
C69H116N26O15S2
Molecular Weight
1613.95
References & Citations
[1]Delporte C, et al. Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur J Pharmacol. 1992;224 (2-3) :183-188.|[2]Kiguchi N, et al. Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice.|[3]Park BM, et al. Attenuation of renovascular hypertension by cyclooxygenase-2 inhibitor partly through ANP release. Peptides. 2015;69:1-8.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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