Laduviglusib
Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy[1][2][3].
Product Specifications
CAS Number
[252917-06-9]
Product Name Alternative
CHIR-99021; CT99021
UNSPSC
12352005
Hazard Statement
H300, H312+H332, H315, H319, H335
Target
Autophagy; GSK-3; Organoid; Wnt; β-catenin
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/laduviglusib.html
Purity
99.76
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C
Molecular Formula
C22H18Cl2N8
Molecular Weight
465.34
Precautions
H300, H312+H332, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3α; GSK-3β
Citation 01
Available Sizes
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