AUTAC4
AUTAC4 is a mitochondria-targeting autophagy-targeting chimera (AUTAC) . AUTAC4 downregulates cytosolic proteins and promotes targeted mitochondrial turnover via mitophagy[1].
Product Specifications
CAS Number
2267315-04-6
UNSPSC
12352005
Target
AUTACs; Mitophagy
Type
Reference compound
Related Pathways
Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/autac4.html
Purity
98.73
Solubility
DMSO : 170 mg/mL (ultrasonic)
Smiles
O=C(NCCCOCCOCCOCCCNC([C@H](CSC1=NC2=C(N=C(N)NC2=O)N1CC3=CC=C(F)C=C3)NC(C)=O)=O)C(C4=C(C5=CC=CC=C5)NC6=C4C=CC=C6)=O
Molecular Formula
C43H48FN9O8S
Molecular Weight
869.96
References & Citations
[1]Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76 (5) :797-810.e10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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