Basroparib
Product Specifications
UNSPSC Description
Basroparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 5.8 nM for TNKS1, exhibiting antitumor activity[1][2].
Target Antigen
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/basroparib.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N=C(N2CCN(CC2)C3=C(C=C(C=C3F)OCCOC)F)NC4=C1N=NN4C
Molecular Weight
421.40
References & Citations
[1]International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.|[2]Bai YR, et al. The recent advance and prospect of poly(ADP-ribose) polymerase inhibitors for the treatment of cancer. Med Res Rev. 2024 Aug 24.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147245/Basroparib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147245/Basroparib-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
1858179-75-5
Available Sizes
Curated Selection
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