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GNF-1331

GNF-1331 (compound 19) is a potent, selective and orally bioavailable porcupine inhibitor (IC50=12 nM) . GNF-1331 blocks Wnt ligand secretion and subsequent Wnt signaling activity, and induces significant antitumor effects in the mouse MMTV-WNT1 xenograft tumor model[1].

Product Specifications

CAS Number

603101-22-0

UNSPSC

12352005

Target

Porcupine; Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gnf-1331.html

Purity

99.84

Smiles

O=C(CSC1=NN=C(N1CCC)C2=CC=NC=C2)NC3=NC4=CC=C(C=C4S3)OC

Molecular Formula

C20H20N6O2S2

Molecular Weight

440.54

References & Citations

[1]Dai Cheng, et al. "Discovery of pyridinyl acetamide derivatives as potent, selective, and orally bioavailable porcupine inhibitors." ACS medicinal chemistry letters 7.7 (2016) : 676-680.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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