Boc-Phe-Leu-Phe-Leu-Phe

Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a N-formyl peptide receptors (FPR) inhibitor. Boc-Phe-Leu-Phe-Leu-Phe abolishes the FMLP-induced release of peptide leukotrienes. Boc-Phe-Leu-Phe-Leu-Phe inhibits the sprouting of human umbilical vein endothelial cell (HUVEC) spheroids mediated by proliferative diabetic retinopathy (PDR) vitreous and vascular endothelial growth factor (VEGF) respectively in a three-dimensional fibrin gel. Boc-Phe-Leu-Phe-Leu-Phe inhibits the anti-inflammatory and antifibrotic effects of Ac2-26 (HY-P1098) . Boc-Phe-Leu-Phe-Leu-Phe can be used for the study of immunology[1][2][3][4][5].

Product Specifications

CAS Number

[73572-58-4]

Product Name Alternative

L-BOC2

UNSPSC

12352209

Target

Leukotriene Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/boc-phe-leu-phe-leu-phe-1.html

Purity

98.03

Solubility

10 mM in DMSO

Smiles

CC(C)(C)OC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)=O)=O)=O

Molecular Formula

C44H59N5O8

Molecular Weight

785.97

References & Citations

[1]Rezzola S, et al. Inflammation and N-formyl peptide receptors mediate the angiogenic activity of human vitreous humour in proliferative diabetic retinopathy. Diabetologia. 2017 Apr;60 (4) :719-728. |[2]Nawaz MI, et al. D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3. Angiogenesis. 2020 Aug;23 (3) :357-369.|[3]Lefer AM, Roth DM, Kugler JL, Smith JB. Modulation of receptor mediated leukotriene release in the perfused heart. Gen Pharmacol. 1986;17 (4) :437-40. |[4]Fan JH, et al. Mechanism of annexin A1/N-formylpeptide receptor regulation of macrophage function to inhibit hepatic stellate cell activation through Wnt/β-catenin pathway. World J Gastroenterol. 2023 Jun 14;29 (22) :3422-3439. |[5]Liao WI, et al. Ac2-26, an Annexin A1 Peptide, Attenuates Ischemia-Reperfusion-Induced Acute Lung Injury. Int J Mol Sci. 2017 Aug 15;18 (8) :1771.