RO-3
RO-3 is a potent, CNS-penetrant, and orally active P2X3 and P2X2/3 antagonist with pIC50s of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. RO-3 shows selectivity for P2X3 and P2X2/3 over all other functional homomultimeric P2X receptors (IC50 >10 μM at P2X1,2,4,5,7) [1].
Product Specifications
CAS Number
[1026582-88-6]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro-3.html
Purity
97.32
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=NC=C(CC2=CC(OC)=C(OC)C=C2C(C)C)C(N)=N1
Molecular Formula
C16H22N4O2
Molecular Weight
302.37
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Ford AP, et al. Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol. 2006;147 Suppl 2 (Suppl 2) :S132-S143.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X2 Receptor; P2X3 Receptor
Available Sizes
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