Clodronic acid (disodium salt)

Clodronic acid (Clodronate) disodium salt, a first-generation bisphosphonate, is orally active osteoclastic bone resorption inhibitor. Clodronic acid disodium salt can be used in high bone turnover states, Paget’s disease and osteolytic bone metastases[1][2][3].

Product Specifications

CAS Number

[22560-50-5]

Product Name Alternative

Clodronate (disodium salt)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/clodronic-acid-disodium-salt.html

Purity

99.0

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=P(C(Cl)(Cl)P(O)(O[Na])=O)(O)O[Na]

Molecular Formula

CH2Cl2Na2O6P2

Molecular Weight

288.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Itoh F, et al. Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis. Inflammation. 2004;28 (1) :15‐21.|[2]Mönkkönen J, et al. Clodronate (dichloromethylene bisphosphonate) inhibits LPS-stimulated IL-6 and TNF production by RAW 264 cells. Life Sci. 1994;54 (14) :PL229‐PL234.|[3]Tanakol R, et al. Clodronic acid in the treatment of postmenopausal osteoporosis. Clin Drug Investig. 2007;27 (6) :419‐433.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|J Adv Res. 2024 Dec 9:S2090-1232 (24) 00565-4.|Phytomedicine. 2025 Mar:138:156429.|Nat Neurosci. 2024 Aug;27 (8) :1522-1533.