Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Biotinylated Human LRP-6 (20-630) Protein, His, Avitag™

LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.

Product Specifications

Background

LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.

Specifications

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) . The protein has a calculated MW of 72.5 kDa. The protein migrates as 80-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

O75581-1

Expression Region

Ala 20 - Pro 630

Host

HEK293

Target

LRP-6

Conjugation

Biotin-labeled

Tag

C-10xHis & C-Avi

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Human R-Spondin 1, His Tag (Cat. No. RS1-H4221) at 1 μg/mL (100 μL/well) can bind Biotinylated Human LRP-6, His,Avitag (Cat. No. LR6-H82E7) with a linear range of 1-39 ng/mL (QC tested).

Format

Powder

Buffer

PBS, pH7.4

Additives

Trehalose

Molecular Weight

72.5 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

RT

Storage Conditions

-20°C

Package Size

200ug*1

Host or Source

HEK293

Species

Human

Protein ID

O75581-1

Preservative

Trehalose

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

GRB10 (Growth Factor Receptor-bound Protein 10, GRB10 Adapter Protein, Insulin Receptor-Binding Protein Grb-IR, GRB10, GRBIR, KIAA0207) discontinued
223063-01 50 µL

GRB10 (Growth Factor Receptor-bound Protein 10, GRB10 Adapter Protein, Insulin Receptor-Binding Protein Grb-IR, GRB10, GRBIR, KIAA0207) discontinued

Ask
View Details
GRB10 (Growth Factor Receptor-bound Protein 10, GRB10 Adapter Protein, Insulin Receptor-Binding Protein Grb-IR, GRB10, GRBIR, KIAA0207) discontinued
223063-02 100 µL

GRB10 (Growth Factor Receptor-bound Protein 10, GRB10 Adapter Protein, Insulin Receptor-Binding Protein Grb-IR, GRB10, GRBIR, KIAA0207) discontinued

Ask
View Details
Protease, Serine 8 (PRSS8)
142001 200 µL

Protease, Serine 8 (PRSS8)

Ask
View Details
Human ST7 knockout cell line
ABC-KH14747 1 Vial

Human ST7 knockout cell line

Ask
View Details
TTLL13 Protein Lysate (Mouse) with C-HA Tag
48726034 100 µg

TTLL13 Protein Lysate (Mouse) with C-HA Tag

Ask
View Details
Mouse Defensin Beta 2 (DEFb2) ELISA Kit
MBS458833-01 48 Tests

Mouse Defensin Beta 2 (DEFb2) ELISA Kit

Ask
View Details