LM-021

LM-021 is a coumarin-chalcone derivative with anti-aggregatory, antioxidant, neuroprotective and anti-inflammatory properties which suppresses nitric oxide (NO), IL-1β, IL-6, TNF-α production, CD68 antigen (CD68) and histocompatibility-2 (MHCII) expression. LM-021 also attenuates the increase of caspase 1 activity, lactate dehydrogenase release and ROS level. LM-021 can be used for neurological research[1].

Product Specifications

CAS Number

[1022282-98-9]

UNSPSC

12352005

Target

Caspase; Interleukin Related; Lactate Dehydrogenase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lm-021.html

Purity

98.27

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN(C1=CC=C(C=C1)/C=C/C(C2=C(C3=CC=CC=C3OC2=O)O)=O)C

Molecular Formula

C20H17NO4

Molecular Weight

335.35

References & Citations

[1]Chen IC, et al. Investigating the therapeutic effects of novel compounds targeting inflammatory IL-1β and IL-6 signaling pathways in spinocerebellar ataxia type 3. Eur J Pharmacol. 2024 Mar 15;967:176370.