VH285-PEG4-C4-Cl

VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC50 of 0.54 μM[1].

Product Specifications

CAS Number

[1799506-07-2]

Product Name Alternative

HaloPROTAC 3

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/vh285-peg4-c4-cl.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N=CS1)=C1C2=CC(OCCOCCOCCOCCCCCCCl)=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)=O)C=C2

Molecular Formula

C41H55ClN4O8S

Molecular Weight

799.42

Precautions

H302, H315, H319

References & Citations

[1]Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10 (8) :1831-7.