UCB-6876
UCB-6876 is a TNFα inhibitor. UCB-6876 can specifically bind to the asymmetric crystalline form of the TNF-α trimer, with a KD of 22 μM[1][2].
Product Specifications
CAS Number
637324-45-9
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ucb-6876.html
Purity
98.49
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
OCC1=NC2=C(N1CC3=CC(C)=CC=C3C)C=CC=C2
Molecular Formula
C17H18N2O
Molecular Weight
266.34
Precautions
H315, H319, H335
References & Citations
[1]Eguida M, et al. Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision. J Cheminform. 2021 Nov 23;13 (1) :90.|[2]O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19;10 (1) :5795.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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