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UCB-6876

UCB-6876 is a TNFα inhibitor. UCB-6876 can specifically bind to the asymmetric crystalline form of the TNF-α trimer, with a KD of 22 μM[1][2].

Product Specifications

CAS Number

637324-45-9

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ucb-6876.html

Purity

98.49

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

OCC1=NC2=C(N1CC3=CC(C)=CC=C3C)C=CC=C2

Molecular Formula

C17H18N2O

Molecular Weight

266.34

Precautions

H315, H319, H335

References & Citations

[1]Eguida M, et al. Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision. J Cheminform. 2021 Nov 23;13 (1) :90.|[2]O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19;10 (1) :5795.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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