UCB-6876

UCB-6876 is a TNFα inhibitor. UCB-6876 can specifically bind to the asymmetric crystalline form of the TNF-α trimer, with a KD of 22 μM[1][2].

Product Specifications

CAS Number

[637324-45-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ucb-6876.html

Purity

98.49

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

OCC1=NC2=C(N1CC3=CC(C)=CC=C3C)C=CC=C2

Molecular Formula

C17H18N2O

Molecular Weight

266.34

Precautions

H315, H319, H335

References & Citations

[1]Eguida M, et al. Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision. J Cheminform. 2021 Nov 23;13 (1) :90.|[2]O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19;10 (1) :5795.