8-Aminoadenosine

8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks Akt/mTOR signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity[1][2][3].

Product Specifications

CAS Number

[3868-33-5]

Product Name Alternative

8-NH2-Ado

UNSPSC

12352005

Hazard Statement

H301

Target

Akt; Apoptosis; Autophagy; DNA/RNA Synthesis; mTOR

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/8-aminoadenosine.html

Purity

99.94

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2N)O[C@@H]1CO

Molecular Formula

C10H14N6O4

Molecular Weight

282.26

Precautions

H301

References & Citations

[1]Mala Shanmugam, et al. Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-aminoadenosine. J Biol Chem. 2009 Sep 25;284 (39) :26816-30.|[2]Jennifer Ann Frey, et al. 8-Amino-adenosine inhibits multiple mechanisms of transcription. Mol Cancer Ther. 2010 Jan;9 (1) :236-45.|[3]Alla Polotskaia, et al. 8-Amino-adenosine activates p53-independent cell death of metastatic breast cancers. Mol Cancer Ther. 2012 Nov;11 (11) :2495-504.