MFZ 10-7
Product Specifications
UNSPSC Description
MFZ 10-7 is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5[1]. MFZ 10-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mfz-10-7.html
Purity
99.70
Solubility
DMSO : 17.86 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
N#CC1=CC(C#CC2=NC(C)=CC=C2)=CC(F)=C1
Molecular Weight
236.24
References & Citations
[1]Keck TM, et al. A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict Biol.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103575/MFZ-10-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103575/MFZ-10-7-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1224431-15-5
Available Sizes
Curated Selection
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