WYE-132
WYE-132 (WYE-125132) is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC50: 0.19±0.07 nM; >5,000-fold selective versus PI3Ks) . WYE-132 (WYE-125132) inhibits mTORC1 and mTORC2.
Product Specifications
CAS Number
[1144068-46-1]
Product Name Alternative
WYE-125132
UNSPSC
12352005
Target
Apoptosis; mTOR
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/WYE-125132.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C2=NC(N3CC4CCC(C3)O4)=C5C(N(N=C5)C6CCC7(CC6)OCCO7)=N2)C=C1)NC
Molecular Formula
C27H33N7O4
Molecular Weight
519.60
References & Citations
[1]Yu K, et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.Cancer Res. 2010 Jan 15;70 (2) :621-631.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; mTORC1; mTORC2
Available Sizes
Curated Selection
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