Siramesine (hydrochloride)

Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM) . Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].

Product Specifications

CAS Number

[224177-60-0]

Product Name Alternative

Lu 28-179 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ferroptosis; Sigma Receptor

Type

Reference compound

Related Pathways

Apoptosis; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Siramesine-hydrochloride.html

Purity

99.69

Solubility

DMSO : ≥ 42 mg/mL

Smiles

FC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=C4C=CC=C5)C6=C2C=CC=C6)C=C1.Cl

Molecular Formula

C30H32ClFN2O

Molecular Weight

491.04

Precautions

H302, H315, H319, H335

References & Citations

Patent. US20220305013A1.|Adv Sci (Weinh). 2023 Mar 11;e2300311.|Dean Francis. 2023 Jun.|J Pharmacol Exp Ther. 2015 Aug;354(2):203-12.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Sigma 1 Receptor

Citation 01

J Am Chem Soc. 2025 Apr 9;147 (14) :11766-11776.|Patent. US20220305013A1.|Adv Sci (Weinh) . 2023 May;10 (13) :e2300311.|Dean Francis. 2023 Jun.|J Pharmacol Exp Ther. 2015 Aug;354 (2) :203-12.