BRD7-IN-2
BRD7-IN-2 (compound 2-77) is a potent inhibitor of bromodomain-containing protein 7 (BRD7), targeting to prostate cancer cells. BRD7-IN-2 is selective for BRD7 rather than BRD9, with IC50s of 5.4 μM, and >300 μM, respectively.
Product Specifications
CAS Number
3032601-06-9
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/brd7-in-2.html
Purity
99.21
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
CN1C2=C(C=CC(C3=CC=C(OC)N=C3OC)=C2)C(C)=CC1=O
Molecular Formula
C18H18N2O3
Molecular Weight
310.35
References & Citations
[1]Ordonez-Rubiano SC, Maschinot CA, Wang S, Sood S, Baracaldo-Lancheros LF, Strohmier BP, McQuade AJ, Smith BC, Dykhuizen EC. Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate Cancer. J Med Chem. 2023 Aug 24;66 (16) :11250-11270.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD7; BRD9
Available Sizes
Frequently Asked Questions
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