BRD7-IN-2

BRD7-IN-2 (compound 2-77) is a potent inhibitor of bromodomain-containing protein 7 (BRD7), targeting to prostate cancer cells. BRD7-IN-2 is selective for BRD7 rather than BRD9, with IC50s of 5.4 μM, and >300 μM, respectively.

Product Specifications

CAS Number

[3032601-06-9]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/brd7-in-2.html

Purity

99.21

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

CN1C2=C(C=CC(C3=CC=C(OC)N=C3OC)=C2)C(C)=CC1=O

Molecular Formula

C18H18N2O3

Molecular Weight

310.35

References & Citations

[1]Ordonez-Rubiano SC, Maschinot CA, Wang S, Sood S, Baracaldo-Lancheros LF, Strohmier BP, McQuade AJ, Smith BC, Dykhuizen EC. Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate Cancer. J Med Chem. 2023 Aug 24;66 (16) :11250-11270.