Temanogrel
Temanogrel is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.
Product Specifications
CAS Number
887936-68-7
Product Name Alternative
APD791
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Temanogrel.html
Purity
98.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1C(C2=C(OCCN3CCOCC3)C=CC(NC(C4=CC=CC(OC)=C4)=O)=C2)=CC=N1
Molecular Formula
C24H28N4O4
Molecular Weight
436.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Xiong Y, et al. Discovery and structure-activity relationship of 3-methoxy-N- (3- (1-methyl-1H-pyrazol-5-yl) -4- (2-morpholinoethoxy) phenyl) benzamide (APD791) : a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis. J Med Chem. 2010 Jun 10;53 (11) :4412-21.|[2]Przyklenk K, et al. Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis. J Thromb Haemost. 2010 Feb;8 (2) :331-40.|[3]Adams JW, et al. APD791, 3-methoxy-n- (3- (1-methyl-1h-pyrazol-5-yl) -4- (2-morpholinoethoxy) phenyl) benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: pharmacological profile, pharmacokinetics, platelet activity and vascular biology. J Pharmacol Exp Ther. 2009 Oct;331 (1) :96-103.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT2 Receptor; α-1 microglobulin
Available Sizes
Frequently Asked Questions
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