Temanogrel

Temanogrel is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.

Product Specifications

CAS Number

[887936-68-7]

Product Name Alternative

APD791

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Temanogrel.html

Purity

98.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1C(C2=C(OCCN3CCOCC3)C=CC(NC(C4=CC=CC(OC)=C4)=O)=C2)=CC=N1

Molecular Formula

C24H28N4O4

Molecular Weight

436.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Xiong Y, et al. Discovery and structure-activity relationship of 3-methoxy-N- (3- (1-methyl-1H-pyrazol-5-yl) -4- (2-morpholinoethoxy) phenyl) benzamide (APD791) : a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis. J Med Chem. 2010 Jun 10;53 (11) :4412-21.|[2]Przyklenk K, et al. Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis. J Thromb Haemost. 2010 Feb;8 (2) :331-40.|[3]Adams JW, et al. APD791, 3-methoxy-n- (3- (1-methyl-1h-pyrazol-5-yl) -4- (2-morpholinoethoxy) phenyl) benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: pharmacological profile, pharmacokinetics, platelet activity and vascular biology. J Pharmacol Exp Ther. 2009 Oct;331 (1) :96-103.