Sinefungin

Sinefungin is a potent inhibitor of virion mRNA (guanine-7-) -methyltransferase, mRNA (nucleoside-2'-) -methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2].

Product Specifications

CAS Number

[58944-73-3]

Product Name Alternative

Adenosyl-Ornithine; A-9145; Antibiotic 32232RP

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; Fungal; Histone Methyltransferase; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sinefungin.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O[C@H]([C@@H]1O)[C@@H](O[C@@H]1C[C@@H](N)CC[C@H](N)C(O)=O)N2C(N=CN=C3N)=C3N=C2

Molecular Formula

C15H23N7O5

Molecular Weight

381.39

Precautions

H302

References & Citations

[1]Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA (guanine-7-) -methyltransferase, mRNA (nucleoside-2'-) -methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253 (12) :4075-7.|[2]Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27 (1) :203-15.