GDC-0879
GDC-0879 is a potent and selective B-Raf inhibitor with an IC50 of 0.13 nM.
Product Specifications
CAS Number
[905281-76-7]
UNSPSC
12352005
Hazard Statement
H228, H302, H317, H319, H341, H351
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GDC-0879.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O/N=C1C(C=CC(C2=CN(CCO)N=C2C3=CC=NC=C3)=C4)=C4CC/1
Molecular Formula
C19H18N4O2
Molecular Weight
334.37
Precautions
H228, H302, H317, H319, H341, H351
References & Citations
[1]Hansen JD, et al. Potent and selective pyrazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 15;18 (16) :4692-5.|[2]Wong H, et al. Pharmacodynamics of 2-[4-[ (1E) -1- (hydroxyimino) -2,3-dihydro-1H-inden-5-yl]-3- (pyridine-4-yl) -1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy. J Pharmacol Exp Ther. 2009 Apr;329 (1) :360-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf
Available Sizes
Curated Selection
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