GDC-0879

GDC-0879 is a potent and selective B-Raf inhibitor with an IC50 of 0.13 nM.

Product Specifications

CAS Number

[905281-76-7]

UNSPSC

12352005

Hazard Statement

H228, H302, H317, H319, H341, H351

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GDC-0879.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O/N=C1C(C=CC(C2=CN(CCO)N=C2C3=CC=NC=C3)=C4)=C4CC/1

Molecular Formula

C19H18N4O2

Molecular Weight

334.37

Precautions

H228, H302, H317, H319, H341, H351

References & Citations

[1]Hansen JD, et al. Potent and selective pyrazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 15;18 (16) :4692-5.|[2]Wong H, et al. Pharmacodynamics of 2-[4-[ (1E) -1- (hydroxyimino) -2,3-dihydro-1H-inden-5-yl]-3- (pyridine-4-yl) -1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy. J Pharmacol Exp Ther. 2009 Apr;329 (1) :360-7.