AZ191
AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM[1].
Product Specifications
CAS Number
1594092-37-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZ191.html
Purity
99.98
Solubility
DMSO : ≥ 30 mg/mL
Smiles
CN1C2=CN=CC=C2C(C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3)=C1
Molecular Formula
C24H27N7O
Molecular Weight
429.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Ashford AL, et al. A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr (286), not Thr (288) . Biochem J. 2014 Jan 1;457 (1) :43-56.|[2]Chen H, et al. Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells. Oncotarget. 2017 Nov 28;9 (17) :13154-13166.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1
Available Sizes
Frequently Asked Questions
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