AZ191

AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM[1].

Product Specifications

CAS Number

[1594092-37-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DYRK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AZ191.html

Purity

99.98

Solubility

DMSO : ≥ 30 mg/mL

Smiles

CN1C2=CN=CC=C2C(C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3)=C1

Molecular Formula

C24H27N7O

Molecular Weight

429.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Ashford AL, et al. A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr (286), not Thr (288) . Biochem J. 2014 Jan 1;457 (1) :43-56.|[2]Chen H, et al. Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells. Oncotarget. 2017 Nov 28;9 (17) :13154-13166.