BAY 41-2272

BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research[1][2].

Product Specifications

CAS Number

[256376-24-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Guanylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/BAY-41-2272.html

Concentration

10mM

Purity

99.60

Solubility

DMSO : 17.5 mg/mL (ultrasonic)

Smiles

NC1=NC(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)=NC=C1C5CC5

Molecular Formula

C20H17FN6

Molecular Weight

360.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Makrynitsa GI, et al. Mapping of the sGC Stimulator BAY 41-2272 Binding Site on H-NOX Domain and Its Regulation by the Redox State of the Heme. Front Cell Dev Biol. 2022 Jun 17;10:925457. |[2]Vogel J, et al. sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension. Hypertens Res. 2021 Dec;44 (12) :1568-1577.