(S, R, S) -AHPC-C2-PEG3-BCN
(S, R, S) -AHPC-C2-PEG3-BCN (Compound 16b) is a VHL ligand, and can be used for synthesis of PROTACs[1].
Product Specifications
CAS Number
[2876198-36-4]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-c2-peg3-bcn.html
Purity
99.22
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCOCCOCCOCCNC(OC[C@@H]4[C@@]5([H])[C@]4([H])CCC#CCC5)=O)=O
Molecular Formula
C42H59N5O9S
Molecular Weight
810.01
References & Citations
[1]Wang Z, et al. Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2. J Am Chem Soc. 2023 Oct 11;145 (40) :21871-21878.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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