HIF-2α-IN-1
Product Specifications
UNSPSC Description
HIF-2α-IN-1 is a HIF-2α inhibitor with an IC50 value of less than 500 nM.
Target Antigen
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/HIF-2_alpha_-IN-1.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC(F)=CC(OC2=CC=C3C([C@@H](O)C(F)(F)S3(=O)=O)=C2C(F)F)=C1
Molecular Weight
405.30
References & Citations
[1]Bruick Richard Keith, et al. HIF-2α inhibitors for treating iron overload disorders. From PCT Int. Appl. (2016), WO 2016057242 A1 20160414.|[2]Dixon Darryl David, et al. Preparation of cyclic sulfone and sulfoximine analogs as HIF-2α inhibitors. From PCT Int. Appl. (2015), WO 2015095048 A1 20150625.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19949/HIF-2α-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19949/HIF-2α-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1799948-06-3
Available Sizes
Curated Selection
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