HIF-2α-IN-1
HIF-2α-IN-1 (compound 9b) is a HIF-2α inhibitor (IC50=1.7 μM, SPA/scintillation proximity assay) [1].
Product Specifications
CAS Number
[1799948-06-3]
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/HIF-2_alpha_-IN-1.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC(F)=CC(OC2=CC=C3C([C@@H](O)C(F)(F)S3(=O)=O)=C2C(F)F)=C1
Molecular Formula
C16H8F5NO4S
Molecular Weight
405.30
References & Citations
[1]Wehn PM, et al. Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S) -3- ((2,2-Difluoro-1-hydroxy-7- (methylsulfonyl) -2,3-dihydro-1 H-inden-4-yl) oxy) -5-fluorobenzonitrile (PT2385) . J Med Chem. 2018 Nov 8;61 (21) :9691-9721.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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