HIF-2α-IN-1

HIF-2α-IN-1 (compound 9b) is a HIF-2α inhibitor (IC50=1.7 μM, SPA/scintillation proximity assay) [1].

Product Specifications

CAS Number

[1799948-06-3]

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/HIF-2_alpha_-IN-1.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=CC(F)=CC(OC2=CC=C3C([C@@H](O)C(F)(F)S3(=O)=O)=C2C(F)F)=C1

Molecular Formula

C16H8F5NO4S

Molecular Weight

405.30

References & Citations

[1]Wehn PM, et al. Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S) -3- ((2,2-Difluoro-1-hydroxy-7- (methylsulfonyl) -2,3-dihydro-1 H-inden-4-yl) oxy) -5-fluorobenzonitrile (PT2385) . J Med Chem. 2018 Nov 8;61 (21) :9691-9721.