Neferine

Neferine is a major bisbenzylisoquinline alkaloid. Neferine strongly inhibits NF-κB activation.

Product Specifications

CAS Number

[2292-16-2]

Product Name Alternative

(-) -Neferine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; NF-κB

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Neferine.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C[C@@H]2N(C)CCC3=C2C=C(OC)C(OC)=C3)C=C1OC4=CC5=C(C=C4OC)CCN(C)[C@@H]5CC6=CC=C(OC)C=C6

Molecular Formula

C38H44N2O6

Molecular Weight

624.77

Precautions

H302, H315, H319, H335

References & Citations

[1]Baskaran R, et al. Neferine prevents NF-κB translocation and protects muscle cells from oxidative stress and apoptosis induced by hypoxia. Biofactors. 2016 Jul 8;42 (4) :407-17.|[2]Liu X, et al. Neferine inhibits proliferation and collagen synthesis induced by high glucose in cardiac fibroblasts and reduces cardiac fibrosis in diabetic mice. Oncotarget. 2016 Sep 20;7 (38) :61703-61715.