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Biotin-PEG4-amide-Alkyne

Biotin-PEG4-amide-Alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG4-amide-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[1006592-45-5]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/biotin-peg4-amide-alkyne.html

Purity

96.41

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCOCCOCCOCCOCCC(NCC#C)=O)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O

Molecular Formula

C24H40N4O7S

Molecular Weight

528.66

Precautions

H315, H319

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Available Sizes

Curated Selection

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