ML-030
ML-030 is a potent PDE4 inhibitor, with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1, and PDE4D2, respectively.
Product Specifications
CAS Number
[1013750-77-0]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ML-030.html
Concentration
10mM
Purity
99.28
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C2=NN3C(SC2)=NN=C3C4=CC(OC)=CC=C4OC)C=C1OC
Molecular Formula
C20H20N4O4S
Molecular Weight
412.46
References & Citations
[1]Skoumbourdis AP, et al. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorg Med Chem Lett. 2009 Jul 1;19 (13) :3686-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4
Available Sizes
Curated Selection
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