Amphiregulin Antibody

Product Specifications

Background

Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-alpha receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant Human Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues.

CAS Number

9007-83-4

NCBI Gene ID

374

Swiss Prot

P15514

Accession Number

P15514

Host

Rabbit

Reactivity

Human

Immunogen

Produced from sera of rabbits immunized with highly pure Recombinant Human Amphiregulin. Anti-Human Amphiregulin-specific antibody was purified by affinity chromatography employing an immobilized Human Amphiregulin matrix.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies, Antibody Pairs

Field of Research

Cancer, Other, Immunology, Neuroscience

Purification

Amphiregulin-specific antibody was purified by affinity chromatography employing an immobilized Human Amphiregulin matrix

Concentration

Batch dependent

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.