Licarin B

Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway[1][2][3].

Product Specifications

CAS Number

[51020-87-2]

Product Name Alternative

(-) -Licarin B

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GLUT; PPAR

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/licarin-b.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(O[C@@H](C2=CC=C3C(OCO3)=C2)[C@@H]4C)C4=CC(/C=C/C)=C1

Molecular Formula

C20H20O4

Molecular Weight

324.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Kim YB, et al. The crystal structure of licarin-B, (C20H20O4), a component of the seeds of Myristica fragrans. Arch Pharm Res. 1991 Mar;14 (1) :1-6.|[2]Cao GY, et al. New inhibitors of nitric oxide production from the seeds of Myristica fragrans. Food Chem Toxicol. 2013 Dec;62:167-71.|[3]G. L. Shyni, et al. Licarin B from Myristica fragrans improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway in 3T3-L1 adipocytes. RSC Adv. 2016.