PF-4800567
PF-4800567 is a potent and selective inhibitor of casein kinase 1 (CK1), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM) .
Product Specifications
CAS Number
1188296-52-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Casein Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/PF-4800567.html
Purity
99.69
Solubility
1 M HCl : 50 mg/mL (ultrasonic) |DMSO : 40 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl)
Smiles
NC1=C2C(N(C3CCOCC3)N=C2COC4=CC=CC(Cl)=C4)=NC=N1
Molecular Formula
C17H18ClN5O2
Molecular Weight
359.81
Precautions
H302, H315, H319, H335
References & Citations
[1]Walton KM, et al. Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther. 2009 Aug;330 (2) :430-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1
Available Sizes
Frequently Asked Questions
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