PF-4800567

PF-4800567 is a potent and selective inhibitor of casein kinase 1 (CK1), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM) .

Product Specifications

CAS Number

[1188296-52-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Casein Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/PF-4800567.html

Purity

99.69

Solubility

1 M HCl : 50 mg/mL (ultrasonic) |DMSO : 40 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl)

Smiles

NC1=C2C(N(C3CCOCC3)N=C2COC4=CC=CC(Cl)=C4)=NC=N1

Molecular Formula

C17H18ClN5O2

Molecular Weight

359.81

Precautions

H302, H315, H319, H335

References & Citations

[1]Walton KM, et al. Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther. 2009 Aug;330 (2) :430-9.