PD-L1-IN-5
Product Specifications
UNSPSC Description
PD-L1-IN-5 (X22) is an orally active PD-L1 inhibitor, with the IC50 value of 785.6 nM. PD-L1-IN-5 has anti-tumor activity in vivo[1].
Target Antigen
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-l1-in-5.html
Solubility
10 mM in DMSO
Smiles
OC1CCN(CCCOC2=CC=CC(C3=CC=CC(COC4=C(Cl)C=C(CN[C@@H](C(OCC)=O)CO)C(OCC5=CC6=NON=C6C=C5)=C4)=C3F)=C2)CC1
Molecular Weight
763.25
References & Citations
[1]Liu L, et al. Discovery of Novel PD-L1 Small-Molecular Inhibitors with Potent In Vivo Anti-tumor Immune Activity. J Med Chem. 2024 Mar 28;67(6):4977-4997.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162357/PD-L1-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162357/
Clinical Information
No Development Reported
CAS Number
2597056-85-2
Curated Selection
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