Trifarotene

Trifarotene (CD5789) is a potent and selective RARγ agonist. Trifarotene (CD5789) shows ～65-fold and ～16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM), respectively[1].

Product Specifications

CAS Number

[895542-09-3]

Product Name Alternative

CD5789

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Autophagy; RAR/RXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Trifarotene.html

Purity

99.12

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C2=CC=C(OCCO)C(C3=CC=C(N4CCCC4)C(C(C)(C)C)=C3)=C2)C=C1)O

Molecular Formula

C29H33NO4

Molecular Weight

459.58

Precautions

H302, H312, H332

References & Citations

[1]Etienne Thoreau, et al. Structure-based design of Trifarotene (CD5789), a potent and selective RARγ agonist for the treatment of acne. Bioorg Med Chem Lett. 2018 Jun 1;28 (10) :1736-1741.|[2]J Aubert, et al. Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene. Br J Dermatol. 2018 Aug;179 (2) :442-456.