Ropinirole (hydrochloride)

Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease[1][2].

Product Specifications

CAS Number

[91374-20-8]

Product Name Alternative

SKF 101468 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H400

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Ropinirole-hydrochloride.html

Purity

99.89

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C(CCN(CCC)CCC)=CC=C2)C1.Cl

Molecular Formula

C16H25ClN2O

Molecular Weight

296.84

Precautions

H302, H400

References & Citations

[1]Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38 (1) : p. 147-54.|[2]Mavrikaki M, et al. Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain. Int J Neuropsychopharmacol. 2014 Dec;17 (12) :1981-93.